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The Scaffold Protein Axin Promotes Signaling Specificity within the Wnt Pathway by Suppressing Competing Kinase Reactions

Maire Gavagan, Erin Fagnan, Elizabeth B. Speltz, Jesse G. Zalatan

2020Cell Systems25 citationsDOIOpen Access PDF

Topics & Concepts

Wnt signaling pathwayGSK-3Scaffold proteinCell biologyPhosphorylationProtein kinase AKinaseCateninSignal transductionBeta-cateninBiologyChemistryBiochemistryWnt/β-catenin signaling in development and cancerCancer-related gene regulationProtein Structure and Dynamics
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