Engineering non-covalently assembled protein nanoparticles for long-acting gouty arthritis therapy
Jinrui Zhang, Yao Sun, Qian Qu, Bo Li, Lili Zhang, Rui Gu, Jianlin Zuo, Wei Wei, Chao Ma, Lei Liu, Kai Liu, Jinɡjinɡ Li, Hongjie Zhang
Abstract
an engineered chimeric protein empowers the construction of potent delivery nanosystems for efficient GA treatment, and this might be adapted for other therapeutics to form long-acting formulations.
Topics & Concepts
Gouty arthritisCovalent bondMaterials scienceNanoparticleMedicineArthritisNanotechnologyInternal medicineChemistryOrganic chemistryGout, Hyperuricemia, Uric AcidStreptococcal Infections and TreatmentsToxin Mechanisms and Immunotoxins