CD8 <sup>+</sup> T cells specific for conserved coronavirus epitopes correlate with milder disease in patients with COVID-19
Vamsee Mallajosyula, Conner Ganjavi, Saborni Chakraborty, Alana M. McSween, Ana Jimena Pavlovitch-Bedzyk, Julie Wilhelmy, Allison Nau, Monali Manohar, Kari C. Nadeau, Mark M. Davis
Abstract
T cells with these conserved specificities are much more abundant in COVID-19 patients with mild disease versus those with a more severe illness, suggesting a protective role.
Topics & Concepts
CoronavirusEpitopeVirologyCoronavirus disease 2019 (COVID-19)AntigenBiologyCD8Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakDiseaseConserved sequenceImmunologyBase sequenceMedicineGeneGeneticsInfectious disease (medical specialty)PathologyOutbreakSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesLong-Term Effects of COVID-19