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Design and synthesis of 1H-pyrazolo[3,4-d]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors

Junjie Zhang, Yan Li, Haotian Tang, Qianqian Zhou, Linjiang Tong, Jian Ding, Hua Xie, Bing Xiong, Tongchao Liu

2023Bioorganic Chemistry14 citationsDOI

Topics & Concepts

KinaseChemistryRegulatorCancer immunotherapyPyrimidineHaematopoiesisCancer researchSelectivityImmunotherapyImmune systemStereochemistryCell biologyBiochemistryBiologyImmunologyStem cellCatalysisGeneMelanoma and MAPK PathwaysCAR-T cell therapy researchCancer therapeutics and mechanisms
Design and synthesis of 1H-pyrazolo[3,4-d]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors | Litcius