Enantioselective organocatalytic amination of 2-perfluoroalkyl-oxazol-5(2<i>H</i>)-ones towards the synthesis of chiral <i>N</i>,<i>O</i>-aminals with perfluoroalkyl and amino groups
Bo Zhu, Tianxiao Yang, Ying‐Xin Gu, Shuping Zhu, Gongming Zhu, Junbiao Chang
Abstract
The first highly enantioselective amination at the C-2 position of oxazol-5(2<italic>H</italic>)-ones has been presented. Two efficient relay asymmetric transformation processes were successfully utilized to synthesize chiral <italic>N</italic>,<italic>O</italic>-aminals with a quaternary center.
Topics & Concepts
Enantioselective synthesisChemistryAminationStereochemistryOrganic chemistryCombinatorial chemistryCatalysisFluorine in Organic ChemistryAsymmetric Synthesis and CatalysisSynthesis and Reactions of Organic Compounds