In vitro models of intracerebral hemorrhage
Bilal Syed, Abhijit Nirwane, Yao Yao
Abstract
Intracerebral hemorrhage (ICH) is a severe clinical emergency caused by bleeding into brain parenchyma. Currently, there are no effective treatments to improve ICH outcomes. Developing new therapies for ICH relies on a thorough understanding of ICH pathophysiology and good in vitro models that enable mechanistic research. In this review, we summarized widely used in vitro ICH models and compared their advantages and disadvantages. Next, key questions that need to be answered in future research are discussed. We aim to provide a quick reference/summary of widely used in vitro ICH models and stimulate the development of new ICH models.
Topics & Concepts
Intracerebral hemorrhageMedicineIntensive care medicineIn vitroNeuroscienceSurgeryPsychologyBiologySubarachnoid hemorrhageBiochemistryIntracerebral and Subarachnoid Hemorrhage ResearchNeurosurgical Procedures and ComplicationsCancer-related gene regulation