IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis
Isaiah R. Turnbull, Monty B. Mazer, Mark H. Hoofnagle, John P. Kirby, Jennifer Leonard, Carlos Mejía-Chew, Andrej Spec, Jane Blood, Sydney Miles, Eric M. Ransom, Robert F. Potter, Joseph P. Gaut, Kenneth E. Remy, Richard S. Hotchkiss
Abstract
Abstract A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.
Topics & Concepts
MedicineImmunotherapyImmunitySepsisDebridement (dental)ImmunologyAntifungalImmune systemDermatologySurgeryAntifungal resistance and susceptibilityFungal Infections and StudiesInfectious Diseases and Mycology