Enhanced Solubility and Bioavailability of Dolutegravir by Solid Dispersion Method: In Vitro and In Vivo Evaluation—a Potential Approach for HIV Therapy
Sunita Chaudhary, Anroop B. Nair, Jigar Shah, Bapi Gorain, Shery Jacob, Hiral Shah, Vimal Patel
Topics & Concepts
DolutegravirBioavailabilitySolubilityDifferential scanning calorimetryDispersion (optics)PoloxamerCmaxAmorphous solidChemistryMaterials scienceChromatographyMiscibilityPharmacokineticsNuclear chemistryPolymerPharmacologyOrganic chemistryHuman immunodeficiency virus (HIV)MedicineAntiretroviral therapyFamily medicineOpticsThermodynamicsViral loadCopolymerPhysicsHIV/AIDS drug development and treatmentDrug Solubulity and Delivery SystemsAdvanced Drug Delivery Systems