A novel thymidine phosphorylase to synthesize (halogenated) anticancer and antiviral nucleoside drugs in continuous flow
Ana I. Benítez‐Mateos, Calvin Klein, David Roura Padrosa, Francesca Paradisi
Abstract
A novel thymidine phosphorylase from H. elongata has been characterized, immobilized, and applied in a flow reactor. With this biocatalyst, four halogenated nucleoside analogues with anticancer and antiviral properties were produced in high yields.
Topics & Concepts
Thymidine phosphorylaseThymidineNucleosidePurine nucleoside phosphorylaseBiocatalysisChemistryCombinatorial chemistryNucleoside analogueCatalysisBiochemistryEnzymeDNAReaction mechanismPurineBiochemical and Molecular ResearchChronic Lymphocytic Leukemia ResearchAdenosine and Purinergic Signaling