Docking Prediction of Amantadine in the Receptor Binding Domain of Spike Protein of SARS-CoV-2
Abdul Mannan Baig, Areeba Khaleeq, Hira Syeda
Abstract
Amantadine has recently been shown to improve patients with COVID-19. In addition to its known mechanism of actions, we performed docking prediction of this drug on the receptor-binding domain of severe acute respiratory syndrome coronavirus 2, SARS-CoV-2. We hypothesize that such interaction may possibly have contributed a role in the clinical improvements reported.
Topics & Concepts
AmantadineDocking (animal)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)CoronavirusSpike Protein2019-20 coronavirus outbreakMemantineReceptorComputational biologyPharmacologyMedicineVirologyBiologyInternal medicineOutbreakInfectious disease (medical specialty)DiseaseNursingNMDA receptorSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesComputational Drug Discovery Methods