Novel fragment-derived colchicine-site binders as microtubule-destabilizing agents
Noelia Montel de la Roche, Tobias Mühlethaler, Rita Maria Concetta Di Martino, Jose Antonio Ortega, Dario Gioia, Bibhas Roy, A.E. Prota, Michel O. Steinmetz, Andrea Cavalli
Topics & Concepts
TubulinChemistryMicrotubuleNocodazoleColchicineSmall moleculeStereochemistryCytoskeletonBinding siteBiophysicsBiochemistryCellCell biologyBiologyGeneticsCancer therapeutics and mechanismsSynthesis and biological activityMicrotubule and mitosis dynamics