Asymmetric Reduction of Aromatic α-Dehydroamino Acid Esters with Water as Hydrogen Source
Yuze Dai, Jingchao Chen, Zheting Wang, Ting Wang, Lin Wang, Yong Yang, Xingfang Qiao, Baomin Fan
Abstract
The asymmetric reduction of aromatic α-dehydroamino acid esters with water as the hydrogen source was developed by a Rh/Cu co-catalytic system. The reaction tolerates various functional groups, providing a valuable synthetic tool to access chiral α-amino acid esters readily. Moreover, the present methodology also was applied in the cost-effective and easy to handle preparation of chiral deuterated α-amino esters by using D2O.
Topics & Concepts
ChemistryDeuteriumCatalysisHydrogenCombinatorial chemistryOrganic chemistryAmino acidReduction (mathematics)Reaction conditionsBiochemistryGeometryMathematicsQuantum mechanicsPhysicsAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisNanomaterials for catalytic reactions