Genomics and functional genomics in Leishmania and Trypanosoma cruzi: statuses, challenges and perspectives
Daniella Castanheira Bartholomeu, Santuza Maria Ribeiro Teixeira, Ângela K. Cruz
Abstract
The availability of Trypanosomatid genomic data in public databases has opened myriad experimental possibilities that have contributed to a more comprehensive understanding of the biology of these parasites and their interactions with hosts. In this review, after brief remarks on the history of the Trypanosoma cruzi and Leishmania genome initiatives, we present an overview of the relevant contributions of genomics, transcriptomics and functional genomics, discussing the primary obstacles, challenges, relevant achievements and future perspectives of these technologies.
Topics & Concepts
Trypanosoma cruziGenomicsBiologyFunctional genomicsLeishmaniaComputational biologyGenomeData scienceGeneticsGeneComputer scienceParasite hostingWorld Wide WebTrypanosoma species research and implicationsResearch on Leishmaniasis StudiesParasites and Host Interactions