Aerobic oxidation of aldehydes to acids in water with cyclic (alkyl)(amino)carbene copper under mild conditions
Songbo Xu, Xiaomin Zhang, Wenjie Xiong, Ping Li, Wentao Ma, Xingbang Hu, Youting Wu
Abstract
This work describes a novel aerobic oxidation of aldehydes with high yields by CAAC-Cu dioxygen activating the C–H bond in water at room temperature.
Topics & Concepts
CarbeneAlkylCopperChemistryAldehydeAmino acidOrganic chemistryMedicinal chemistryCatalysisPolymer chemistryPhotochemistryBiochemistryCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsSynthetic Organic Chemistry Methods