mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice
Jaeyong Kim, Kyeongseok Jeon, Sang‐In Park, Yoo‐Jin Bang, Hyeong-Jun Park, Hye Won Kwak, Do‐Hyung Kim, Sooyeon Lee, Eun‐Jin Choi, Nam‐Hyuk Cho, Jae‐Hwan Nam
Abstract
We developed a promising mRNA vaccine against severe fever with thrombocytopenia syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. Administration of lipid nanoparticle-encapsulated mRNA-Gn successfully induced neutralizing antibodies and T-cell responses in mice. The vaccinated mice were protected against a lethal SFTS virus challenge, suggesting that this mRNA vaccine may be an effective and successful SFTS vaccine candidate.
Topics & Concepts
Severe fever with thrombocytopenia syndromeVirologyVirusMessenger RNAImmunologyAntibodyNeutralizing antibodyTickBiologyMedicineGeneBiochemistryViral Infections and VectorsViral Infections and Outbreaks ResearchVector-Borne Animal Diseases