Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia
Mark B. Leick, Harrison Silva, Irene Scarfò, Rebecca C. Larson, Bryan D. Choi, Amanda A. Bouffard, Kathleen Gallagher, Andrea Schmidts, Stefanie R. Bailey, Michael C. Kann, Max Jan, Marc Wehrli, Korneel Grauwet, Nora Horick, Matthew J. Frigault, Marcela V. Maus
Topics & Concepts
Myeloid leukemiaChimeric antigen receptorCancer researchMyeloidAntigenAvidityCytotoxic T cellCD8BiologyImmunologyImmunotherapyCell biologyImmune systemIn vitroBiochemistryCAR-T cell therapy researchNanowire Synthesis and ApplicationsVirus-based gene therapy research