A 19-Year-Old Adolescent with Probable Alzheimer’s Disease1
Jianping Jia, Yue Zhang, Yuqing Shi, Xuping Yin, Shiyuan Wang, Yan Li, Tan Zhao, Wenying Liu, Aihong Zhou, Longfei Jia
Abstract
Alzheimer's disease (AD) primarily affects older adults. In this report, we present the case of a 19-year-old male with gradual memory decline for 2 years and World Health Organization-University of California Los Angeles Auditory Verbal Learning Test (WHO-UCLA AVLT) results also showing memory impairment. Positron emission tomography-magnetic resonance imaging with 18F fluorodeoxyglucose revealed atrophy of the bilateral hippocampus and hypometabolism in the bilateral temporal lobe. Examination of the patient's cerebrospinal fluid showed an increased concentration of p-tau181 and a decreased amyloid-β 42/40 ratio. However, through whole-genome sequencing, no known gene mutations were identified. Considering the above, the patient was diagnosed with probable AD.