Polyglutamic Acid-Grafted Halloysite-Modified Collagen-Sodium Alginate Oxide Composite Membrane for Wound Dressing Application
Changkai Yang, Yanping Huang, Nianhua Dan, Yining Chen
Abstract
Introducing nanomaterials is an effective strategy for enhancing the mechanical properties of collagen (COL) composite membranes. In this work, we obtained a carboxylated halloysite nanotubes (HNTs) nanomaterial by grafting a macromolecular substance polyglutamic acid (γ-PGA) on the surface of HNTs, which was coblended with collagen matrix to obtain a collagen-based composite membrane with good mechanical properties under the cross-linking effect of sodium alginate oxide (ADA). We investigated that the γ-PGA-grafted HNTs have the potential to improve and enhance the tensile strength and elongation at the break of the collagen membranes. A study of contact angle of composite membranes revealed the γ-PGA-grafted HNTs inhibited the negative effects of HNTs on the hydrophilicity of the COL-ADA membrane. The biological properties of carboxylated HNTs composite-modified collagen-sodium alginate oxide composite membrane (COL-c-ADA) were evaluated in vivo and virto. Polyglutamic acid-grafted HNTs composite-modified collagen-sodium alginate oxide composite membrane material is nontoxic and can promote cell proliferation and migration to promote wound healing.