Type I interferon induces cancer stem cells-mediated chemotherapy resistance
Mara De Martino, Claire Vanpouille‐Box
Abstract
. demonstrate that suboptimal type I interferon (IFN-I) signaling in tumors undergoing immunogenic cell death (ICD) facilitates the accumulation of cancer stem cells (CSCs) by triggering the epigenetic regulator lysine demethylase 1B (KDM1B). KDM1B stands out as a promising target for the development of novel strategies to improve anti-cancer responses driven by ICD.
Topics & Concepts
DemethylaseCancer stem cellCancer researchInterferonRegulatorStem cellCancer cellCancerImmunologyBiologyChemotherapyEpigeneticsMedicineCell biologyInternal medicineGeneticsGeneEpigenetics and DNA MethylationImmune cells in cancerCancer Immunotherapy and Biomarkers