Knockout mouse models reveal the contributions of G protein subunits to complement C5a receptor–mediated chemotaxis
Esther van den Bos, Benjamin Ambrosy, Markus Horsthemke, Stefan Walbaum, Anne C. Bachg, Nina Wettschureck, Giulio Innamorati, Thomas M. Wilkie, Peter J. Hanley
Abstract
signaling, and membrane protrusive activity is promoted by G proteins that deplete phosphatidylinositol 4,5-bisphosphate.
Topics & Concepts
ChemotaxisCell biologyC5a receptorBiologyHeterotrimeric G proteinReceptorSignal transductionKnockout mouseG proteinComplement systemImmunologyImmune systemBiochemistryComplement system in diseasesReceptor Mechanisms and SignalingMonoclonal and Polyclonal Antibodies Research