Divergent Effects of Dnmt3a and Tet2 Mutations on Hematopoietic Progenitor Cell Fitness
Elizabeth L. Ostrander, Ashley C. Kramer, Cates Mallaney, Hamza Celik, Won Kyun Koh, Jake Fairchild, Emily Haussler, Christine Zhang, Grant A. Challen
Abstract
) than loss of Dnmt3a, which is associated with a more rapid expansion of committed progenitor cells. The effect of Tet2 mutation manifests more profound myeloid lineage skewing in committed hematopoietic progenitor cells rather than long-term HSCs. Molecular characterization revealed divergent transcriptomes and chromatin accessibility underlying these functional differences.
Topics & Concepts
BiologyHaematopoiesisProgenitor cellProgenitorGeneticsMutationHematopoietic cellCancer researchStem cellImmunologyComputational biologyGeneAcute Myeloid Leukemia ResearchHematopoietic Stem Cell TransplantationEpigenetics and DNA Methylation