Coaxial dual-path electrochemical biosensing and logic strategy-based detection of lung cancer-derived exosomal PD-L1
J. Liu, Liu Zd, Chun-Qin Zhao, Yuting Jiao, B. Li, Jiaju Shi, Zichao Chen, Zhen Zhang
Abstract
particles per mL, and the detection limit was 310 particles per mL. Compared to other sensors, the electrochemical biosensor designed in this study has a lower detection limit and a wider detection range. Furthermore, we also successfully identified lung cancer-derived ExoPD-L1 by analyzing multiple protein biomarkers expressed on exosomes through the "AND" logic strategy. This sensor platform is expected to realize highly sensitive detection and accurate analysis of multiple sources of ExoPD-L1 and provide ideas for the clinical detection of ExoPD-L1.
Topics & Concepts
Detection limitBiosensorLung cancerAptamerMaterials scienceMicrovesiclesAnalyteNanotechnologyCancer biomarkersCancer researchCancerChemistrymicroRNABiologyMolecular biologyChromatographyMedicineBiochemistryOncologyInternal medicineGeneAdvanced biosensing and bioanalysis techniquesExtracellular vesicles in diseaseAnodic Oxide Films and Nanostructures