Natural isoflavone formononetin inhibits IgE-mediated mast cell activation and allergic inflammation by increasing IgE receptor degradation
Ziwen Zhou, Kunmei Ji, Xue-Yan Zhu, Xinying Wu, Ruo-Tong Lin, Chu-Chu Xie, Ze‐Lang Cai, Jiajie Chen
Abstract
increased proteasome-mediated degradation, and induced FcεRIγ ubiquitination by inhibiting USP5 and/or USP13. FNT and USP inhibition may be useful for suppressing IgE-mediated allergic diseases.
Topics & Concepts
Immunoglobulin EAllergic inflammationMast cellInflammationImmunologyReceptorChemistryBiologyAntibodyBiochemistryMast cells and histamineImmune Cell Function and InteractionNeuropeptides and Animal Physiology