Poly(ethylene glycol)-mediated mineralization of metal–organic frameworks
Qun Yu, Yuan Tian, Meng Li, Yuan Jiang, Haifeng Sun, Guiqiang Zhang, Zhiliang Gao, Wei Zhang, Jingcheng Hao, Ming Hu, Jiwei Cui
Abstract
We report a one-pot approach for the scalable synthesis of zeolitic imidazolate framework-8 nanoparticles (ZIF-8 NPs) using poly(ethylene glycol) as the mineralizer, where drugs and proteins can be encapsulated in the ZIF-8 NPs for intracellular delivery. The ZIF-8 NPs exhibit high colloidal dispersity and stability (above two weeks) in cell medium.
Topics & Concepts
Ethylene glycolDispersityNanoparticleImidazolateZeolitic imidazolate frameworkChemical engineeringChemistryMineralization (soil science)Metal-organic frameworkMetalColloidNanotechnologyMaterials scienceOrganic chemistryAdsorptionNitrogenEngineeringMetal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranosticsNanoparticle-Based Drug Delivery