Cooling-induced, localized release of cytotoxic peptides from engineered polymer nanoparticles in living mice for cancer therapy
Hiroyuki Koide, Kazuhiro Saito, Keiichi Yoshimatsu, Beverly Chou, Yu Hoshino, Sei Yonezawa, Naoto Oku, Tomohiro Asai, Kenneth J. Shea
Topics & Concepts
MelittinLower critical solution temperatureIn vivoDrug deliveryBiophysicsPolymerChemistryDrugNanotechnologyMaterials sciencePharmacologyPeptideBiochemistryCopolymerOrganic chemistryMedicineBiologyBiotechnologyNanoparticle-Based Drug DeliveryLipid Membrane Structure and BehaviorRNA Interference and Gene Delivery