TFRC promotes epithelial ovarian cancer cell proliferation and metastasis via up-regulation of AXIN2 expression.
Yake Huang, Jiani Huang, Yan Huang, Lei Gan, Ling Long, Aimin Pu, Rongkai Xie
Abstract
. More significantly, we demonstrated that TFRC-mediated proliferation and metastasis of EOC cells resulted from its positive regulation of AXIN2 expression. In conclusion, our findings suggest that TFRC accelerates the progression of EOC by promoting cancer cell proliferation and metastasis via upregulation of AXIN2 expression, which highlights its potential as a novel therapeutic target for human EOC.
Topics & Concepts
Gene knockdownDownregulation and upregulationCancer researchMetastasisAXIN2Cell growthOvarian cancerCancerMedicineBiologyInternal medicineCell cultureWnt signaling pathwaySignal transductionCell biologyBiochemistryGeneGeneticsKruppel-like factors researchIron Metabolism and DisordersOvarian cancer diagnosis and treatment