Chronic stress dysregulates the Hippo/YAP/14-3-3η pathway and induces mitochondrial damage in basolateral amygdala in a mouse model of depression
Yan Zhao, Yulong Chen, Chihua Guo, Pingping Li, Zhao Cheng, Lei Zheng, Baoyong Sha, Hao Xu, Xingli Su, Yunpeng Wang
Abstract
: The integrated Hippo/YAP/14-3-3η pathway in the BLA neuron is critical in mediating depressive-like behaviors in mice, suggesting a causal role for this pathway in susceptibility to chronic stress-induced depression. This pathway therefore may present a therapeutic target against mitochondrial dysfunction and synaptic impairment in MDD.
Topics & Concepts
Basolateral amygdalaDepression (economics)Cell biologyChronic stressAmygdalaHippo signaling pathwayChemistryNeuroscienceBiologyKinaseMacroeconomicsEconomics14-3-3 protein interactionsHippo pathway signaling and YAP/TAZ