Suppression of RNA editing by miR-17 inhibits the stemness of melanoma stem cells
Yu Zhang, Xiaoyuan Yang, Yalei Cui, Xiaobo Zhang
Abstract
mRNA editing upregulated the expressions of stemness and anti-apoptotic genes by activating Rac1 and then phosphorylating Akt and NF-κB, thus leading to oncogenesis of melanoma stem cells. Our findings contribute new perspectives to miRNA-regulated RNA editing in tumor progression.
Topics & Concepts
Stem cellRNA editingBiologyMelanomamicroRNACancer researchCarcinogenesisRNACancer stem cellCell biologyGeneGeneticsRNA regulation and diseaseCRISPR and Genetic EngineeringMicroRNA in disease regulation