Nickel‐Catalyzed Reductive Acylation of Carboxylic Acids with Alkyl Halides and <i>N</i>‐Hydroxyphthalimide Esters Enabled by Electrochemical Process
Xiao Zhou, Lin Guo, Haoxiang Zhang, Raymond Yang Xia, Chao Yang, Wujiong Xia
Abstract
Abstract A sustainable Ni‐catalyzed reductive acylation reaction of carboxylic acids via an electrochemical pathway is presented, affording a variety of ketones as major products. The reaction proceeds at ambient temperature using unactivated alkyl halides and N ‐hydroxyphthalimide (NHP) esters as coupling partners, which exhibits several synthetic advantages, including mild conditions and convenience of amplification (58% yield for 6 mmol scale reaction). magnified image
Topics & Concepts
ChemistryHalideAlkylAcylationCatalysisYield (engineering)NickelElectrochemistryCarboxylic acidOrganic chemistryCoupling reactionCombinatorial chemistryElectrodePhysical chemistryMaterials scienceMetallurgyCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsCatalytic Cross-Coupling Reactions