Long-lasting analgesia via targeted in situ repression of Na <sub>V</sub> 1.7 in mice
Ana M. Moreno, Fernando Alemán, Glaucilene Ferreira Catroli, Matthew A. Hunt, Michael Hu, Amir Dailamy, Andrew Pla, Sarah A. Woller, Nathan Palmer, Udit Parekh, Daniella McDonald, Amanda J. Roberts, Vanessa Goodwill, Ian Dryden, Robert F. Hevner, Lauriane Delay, Gilson Gonçalves dos Santos, Tony L. Yaksh, Prashant Mali
Abstract
In situ genome targeting of Na V 1.7 via CRISPRs and zinc fingers enables genomically scarless, durable, and nonaddictive management of pain.
Topics & Concepts
NociceptionChronic painAddictionMedicineMutationPsychological repressionNeuroscienceBioinformaticsPharmacologyAnesthesiaBiologyGeneticsInternal medicineGeneReceptorGene expressionPain Mechanisms and TreatmentsNeuroscience and Neuropharmacology ResearchIon channel regulation and function