Сardiac injury in rats with experimental posttraumatic stress disorder and mechanisms of its limitation in experimental posttraumatic stress disorder-resistant rats
Е. Б. Манухина, В. Э. Цейликман, Maria Komelkova, Maxim Lapshin, Anna V. Goryacheva, М. V. Kondashevskaya, V. A. Mkhitarov, С. С. Лазуко, Olga B. Tseilikman, Alexey Sarapultsev, Y. A. Dmitrieva, В. К. Стрижиков, O. P. Kuzhel, H. Fred Downey
Abstract
For the first time, rats exposed to stress were segregated into experimental PTSD (ePTSD)-susceptible and ePTSD-resistant rats. Cardiac injury, ECG changes, and impaired exercise tolerance were more pronounced in ePTSD-susceptible rats. Resistance to ePTSD was associated with decreased inflammation and oxidative stress and with increased protective heat shock protein 70. Results may help identify individuals at high risk of PTSD and also provide a foundation for developing preventive and therapeutic means to restrict PTSD-associated cardiac morbidity.