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Access to Unsymmetrically Substituted Diaryl Gold N‐Acyclic Carbene (NAC) and N‐Heterocyclic Carbene (NHC) Complexes via the Isonitrile Route

Vanessa Vethacke, Vanessa Claus, Martin C. Dietl, Daniel Ehjeij, Arne Meister, Jonas F. Huber, Leon K. Paschai Darian, Matthias Rudolph, Frank Röminger, A. Stephen K. Hashmi

2021Advanced Synthesis & Catalysis15 citationsDOIOpen Access PDF

Abstract

Abstract A variety of unsymmetric diaryl gold N‐acyclic c arbene (NAC) complexes was synthesized via the isonitrile route by three different methods: (a) solvent free in a melt, (b) mechanochemically and (c) in THF at room temperature. The latter method can also be used to synthesize unsaturated gold NHC complexes. These methods overall offer access to a broad array of new complexes and remove one of the previous limitations of the isonitrile route to NAC and NHC complexes of gold, namely the inability to react with the less nucleophilic aromatic amines. The new complexes also proved to be successful as pre‐catalysts in the gold‐catalyzed phenol synthesis. magnified image

Topics & Concepts

CarbeneChemistryNucleophileCatalysisSolventPhenolCombinatorial chemistryMedicinal chemistryOrganic chemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsCatalytic Alkyne Reactions
Access to Unsymmetrically Substituted Diaryl Gold N‐Acyclic Carbene (NAC) and N‐Heterocyclic Carbene (NHC) Complexes via the Isonitrile Route | Litcius