Macrophage-targeting oligopeptides from <i>Mortierella alpina</i>
Jacob M. Wurlitzer, Aleksa Stanišić, Sebastian Ziethe, Paul M. Jordan, K Günther, Oliver Werz, Hajo Kries, Markus Gressler
Abstract
oligopeptides as carrier peptides for directed cell targeting. The current study demonstrates substrate-specificity testing as a powerful tool to identify flexible NRPS modules and highlights basal fungi as reservoir for chemically tractable compounds in pharmaceutical applications.
Topics & Concepts
Nonribosomal peptideOligopeptideBiosynthesisSubstrate specificityBiochemistryAdenylylationEnzymeBiologySubstrate (aquarium)PeptideFluorophoreChemistryFluorescencePhysicsEcologyQuantum mechanicsMicrobial Natural Products and BiosynthesisAntimicrobial Peptides and ActivitiesMarine Sponges and Natural Products