Replacing DMF in solid-phase peptide synthesis: varying the composition of green binary solvent mixtures as a tool to mitigate common side-reactions
Sandip V. Jadhav, Vincent Martin, Peter H. G. Egelund, Henrik Johansson, Tobias Krüger, Franziska Richner, Sebastian T. Le Quement, Fernando Alberício, Frank Dettner, Carolin C. Lechner, Ralph Schönleber, Daniel Sejer Pedersen
Abstract
The composition of green binary solvent mixtures is used as a tool to mitigate side-reactions in SPPS.
Topics & Concepts
SolventPhase (matter)Composition (language)Binary numberChemistryCombinatorial chemistryOrganic chemistryChemical engineeringMathematicsArithmeticLinguisticsPhilosophyEngineeringChemical Synthesis and AnalysisClick Chemistry and ApplicationsRNA and protein synthesis mechanisms