Multitarget Biological Profiling of New Naphthoquinone and Anthraquinone-Based Derivatives for the Treatment of Alzheimer’s Disease
Marta Campora, Claudio Canale, Elena Gatta, Bruno Tasso, Erik Laurini, Annalisa Relini, Sabrina Pricl, Marco Catto, Michele Tonelli
Abstract
toxicity in primary cultures of cerebellar granule cells. Therefore, our findings demonstrate that these molecules may represent valuable chemotypes toward the development of promising candidates for AD therapy.
Topics & Concepts
ChemistryNeuroprotectionAcetylcholinesteraseBiochemistryIC50NaphthoquinoneStereochemistryPharmacologyEnzymeIn vitroBiologyOrganic chemistryAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery Methods