Amplified Electrochemical Sensor for Nano-molar Detection of Morphine in Drug Samples
Samad Zare, Mojtaba Masomi, Mazyar Sharifzadeh Baei, Shahram Naghizadeh Raeisi, Seyed‐Ahmad Shahidi
Abstract
In this research, carbon paste electrode (CPE) was modified with MgO/SWCNTs nanocomposite and 1-methyl-3-octylimidazolium tetrafluoroborate (MOCITFB) and then used as a highly sensitive analytical approach for the determination of morphine in drug samples. In this study, the MgO/SWCNTs was synthesized using the simple precipitation method. The TEM image displayed the decoration of MgO nanoparticles with diameter ⁓ 40 nm at surface of SWCNTs. In addition, the electrochemical behavior of morphine was also investigated at surface of MgO/SWCNTs/MOCITFB/CPE with different pH values. The findings displayed an electro-oxidation mechanism in the presence of one electron and one proton. Moreover, the oxidation signal of morphine showed a linear calibration curve in the concentration range of 3.0 nM to 320 μM with the detection limit pf 0.8 nM at surface of MgO/SWCNTs/MOCITFB/CPE. Moreover, the MgO/SWCNTs/MOCITFB/CPE was successfully used for the determination of morphine in injection sample with recovery range of 98.41% to 102.49%.