Nickel-catalyzed alkylation of ketones and nitriles with primary alcohols
Sertaç Genç, Burcu Arslan, Derya Gülcemal, Süleyman Gülcemal, Salih Günnaz
Abstract
Nickel(II)-salen or nickel(II)-salphen catalyzed α-alkylation of ketones and nitriles with primary alcohols is reported. Various α-alkylated ketones and nitriles were obtained in high yields through a borrowing hydrogen strategy by using 1-3 mol% of nickel catalyst and a catalytic amount of NaOH (5-10 mol%) under aerobic conditions.
Topics & Concepts
AlkylationChemistryCatalysisPrimary (astronomy)NickelHydrogenOrganic chemistryAstronomyPhysicsAsymmetric Hydrogenation and CatalysisCarbon dioxide utilization in catalysisCatalytic C–H Functionalization Methods