Design, synthesis and anti-hepatocellular carcinoma activity of 3-arylisoquinoline alkaloids
Xuemei Deng, Tian Luo, Li Zhao, Huaixiu Wen, Honghua Zhang, Xiaoyan Yang, Lei Fang, Dan Liu, Tao Shi, Quanyi Zhao, Zhen Wang
Topics & Concepts
ChemistryIn vivoPI3K/AKT/mTOR pathwayApoptosisIn vitroProtein kinase BCell growthHepatocellular carcinomaIC50PharmacologyEtoposideStereochemistryCell cycle checkpointCell cycleCancer researchBiochemistryChemotherapyInternal medicineBiologyMedicineBiotechnologyCancer therapeutics and mechanismsQuinazolinone synthesis and applicationsSynthesis and Biological Activity