Central Nervous System Cell‐Derived Exosomes in Neurodegenerative Diseases
Yang Tian, Chen Fu, Yifan Wu, Yao Lu, Xuemei Liu, Zhang Yunling
Abstract
Exosomes are a type of extracellular vesicles secreted by almost all kinds of mammalian cells that shuttle "cargo" from one cell to another, indicative of its role in cell-to-cell transportation. Interestingly, exosomes are known to undergo alterations or serve as a pathway in multiple diseases, including neurodegenerative diseases. In the central nervous system (CNS), exosomes originating from neurons or glia cells contribute to or inhibit the progression of CNS-related diseases in special ways. In lieu of this, the current study investigated the effect of CNS cell-derived exosomes on different neurodegenerative diseases.
Topics & Concepts
MicrovesiclesCentral nervous systemCellBiologyCell typeCell biologyNeuroscienceExtracellular vesiclesExtracellularNervous systemmicroRNABiochemistryGeneExtracellular vesicles in diseaseAmyotrophic Lateral Sclerosis ResearchNeuroinflammation and Neurodegeneration Mechanisms