Sex-based differences in histology, staging, and prognosis among 2983 gastric cancer surgery patients
Yonghoon Choi, Nayoung Kim, Ki Wook Kim, Hyeong Ho Jo, Jae‐Hyung Park, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Dong Ho Lee, Hyeon Jeong Oh, Hye Seung Lee, Young Suk Park, Sang-Hoon Ahn, Yun‐Suhk Suh, Do Joong Park, Hyung‐Ho Kim, Ji‐Won Kim, Jin Won Kim, Keun‐Wook Lee, Won Chang, Ji Hoon Park, Yoon Jin Lee, Kyoung Ho Lee, Young Hoon Kim
Abstract
BACKGROUND: Few studies have been conducted on sex differences in the incidence, pathophysiology, and prognosis of gastric cancer (GC). AIM: To analyze the differences in GC characteristics according to sex in patients who underwent surgical treatment for GC. METHODS: A total of 2983 patients diagnosed with gastric adenocarcinoma who received surgical treatment at the Seoul National University Bundang Hospital between 2003 and 2017 were included. Baseline clinicopathological characteristics, histologic type of GC, overall and GC-specific survival rates, and associated risk factors were analyzed. RESULTS: = 0.045). The risk factors for GC-related mortality were older age, upper location of GC, and diffuse- or mixed-type histology. In terms of comorbidities, more males died from diseases other than GC, including other malignancies such as lung cancer, hepatocellular carcinoma, and pancreatic cancer, and respiratory diseases such as interstitial lung disease and chronic obstructive pulmonary disease, while there were relatively more cardiovascular or cerebrovascular deaths in females. CONCLUSION: Sex-based differences in GC were observed in clinicopathological features, including age at diagnosis, tumor location, histologic type, survival rate, and comorbidities.