Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents
Avinash G. Vishakantegowda, Dasom Hwang, Prashant Chakrasali, Eunhye Jung, Joo‐Youn Lee, Jin Soo Shin, Young‐Sik Jung
Abstract
value of 0.016 μM for PI4KIIIβ, but not for PI4KIIIα (>10 μM). Therefore, 7f represents a highly potent and selective PI4KIIIβ inhibitor for the further development of antiviral therapy against hRVs or other enteroviruses.
Topics & Concepts
BiologyKinaseBiochemistryQuinazolinone synthesis and applicationsCalcium signaling and nucleotide metabolismViral Infections and Immunology Research