6-Arylmethylidene Penicillin-Based Sulfone Inhibitors for Repurposing Antibiotic Efficiency in Priority Pathogens
Diana Rodríguez, Marı́a Maneiro, Juan Carlos Vázquez-Ucha, Alejandro Beceiro, Concepción González‐Bello
Abstract
strains carrying class C (CMY-2 and DHA-1) and class A (TEM-1 and CTX-M-2) β-lactamase enzymes, respectively. Kinetic and inhibition studies with the OXA-24/40 enzyme, protein mass spectrometry analysis and docking studies allowed us to gain an insight into the inhibition mechanism and the experimentally observed differences between the ligands.
Topics & Concepts
ImipenemChemistryAntibioticsPenicillinMicrobiologyEnzymeCarbapenemAmpicillinCeftazidimeBacteriaBiochemistryAntibiotic resistanceBiologyPseudomonas aeruginosaGeneticsAntibiotic Resistance in BacteriaAntibiotics Pharmacokinetics and EfficacyPharmaceutical and Antibiotic Environmental Impacts