Programmability of dual-color DNA-templated silver nanoclusters for modular design of FRET aptasensors toward multiplexed detection
Mustafa Hussain, Yue Liu, Chengquan Wang, Huiyuan Yang, Kawtar Ettayri, Yu Chen, Kun Wang, Lingliang Long, Jing Qian
Abstract
By exploiting the programmability of DNA, dual-color DNA-templated silver nanoclusters have been synthesized to serve as a label-free fluorescent probe with a G5-linker at the 3' end. This advancement facilitates the modular design of universal FRET-based aptasensors using aptamers with a C5-linker at the 3' end for multiplexed detection, making them easily switch their applications.
Topics & Concepts
NanoclustersModular designFörster resonance energy transferNanotechnologyMultiplexingMaterials scienceDual (grammatical number)Computer scienceChemistryFluorescencePhysicsOpticsArtTelecommunicationsLiteratureOperating systemAdvanced biosensing and bioanalysis techniquesNanocluster Synthesis and ApplicationsAdvanced Nanomaterials in Catalysis