Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic-associated fatty liver disease
Xin Luo, Shengzheng Luo, Zixin Xu, Cui Zhou, Zhenghong Li, Xiaoyan Zhou, Mingyi Xu
Abstract
BACKGROUND: Exosomes play an important role in metabolic-associated fatty liver disease (MAFLD), but the mechanism by which exosomes participate in MAFLD still remain unclear. AIM: To figure out the function of lipotoxic exosomal miR-1297 in MAFLD. METHODS: . RESULTS: modulating the PI3K/AKT signaling pathway. CONCLUSION: miR-1297 was overexpressed in exosomes derived from lipotoxic hepatocytes. The lipotoxic hepatocyte-derived exosomal miR-1297 could promote the activation and proliferation of hepatic stellate cells through the PTEN/PI3K/AKT signaling pathway, accelerating the progression of MAFLD.
Topics & Concepts
PTENFatty liverHepatic stellate cellHepatocyteSignal transductionCancer researchCell biologySteatosisChemistryBiologyDiseaseMedicineInternal medicinePI3K/AKT/mTOR pathwayEndocrinologyBiochemistryIn vitroLiver Disease Diagnosis and TreatmentLiver Disease and TransplantationLiver Diseases and Immunity