EXO70D isoforms mediate selective autophagic degradation of type-A ARR proteins to regulate cytokinin sensitivity
Atiako Kwame Acheampong, Carly M. Shanks, Chia‐Yi Cheng, G. Eric Schaller, Yasin Dagdas, Joseph J. Kieber
Abstract
Significance One of the central regulators of plant growth and development is the phytohormone cytokinin. Likewise, it has become increasingly apparent that autophagy is a critical regulatory process in both plants and animals. Our work provides a mechanistic link between these regulatory processes, demonstrating that autophagy can fine-tune cytokinin perception by modulating the level of the type-A ARRs, which negatively regulate the cellular response to cytokinin. Further, our work sheds light on the mechanism of selective autophagy and on how a particular cargo is targeted for autophagic degradation by a novel autophagy receptor belonging to the EXO70D gene family.