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Design, synthesis, and biological evaluation of 4-(2-fluorophenoxy)-7-methoxyquinazoline derivatives as dual EGFR/c-Met inhibitors for the treatment of NSCLC

Sheng Tang, Chuanchuan Sun, Xintao He, Wenhui Gan, Linxiao Wang, Dan Qiao, Xinyu Guan, Shan Xu, Pengwu Zheng, Wufu Zhu

2023European Journal of Medicinal Chemistry15 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryEpidermal growth factor receptorA549 cellApoptosisEGFR inhibitorsPharmacologyProtein kinase BAfatinibIn vivoCell cycle checkpointCell growthCell cycleC-MetCancer researchReceptorErlotinibBiochemistryHepatocyte growth factorBiologyBiotechnologyLung Cancer Treatments and MutationsHER2/EGFR in Cancer ResearchPeptidase Inhibition and Analysis
Design, synthesis, and biological evaluation of 4-(2-fluorophenoxy)-7-methoxyquinazoline derivatives as dual EGFR/c-Met inhibitors for the treatment of NSCLC | Litcius