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Formation of transient highly-charged mAb clusters strengthens interactions with host cell proteins and results in poor clearance of host cell proteins by protein A chromatography

Haibin Luo, Qun Du, Chen Qian, Michelle Mlynarczyk, Timothy M. Pabst, Melissa Damschroder, Alan K. Hunter, William K. Wang

2022Journal of Chromatography A21 citationsDOI

Topics & Concepts

ChemistryMonoclonal antibodyArginineChromatographyElutionBiophysicsBiochemistryAntibodyAmino acidBiologyImmunologyMonoclonal and Polyclonal Antibodies ResearchProtein purification and stabilityViral Infectious Diseases and Gene Expression in Insects
Formation of transient highly-charged mAb clusters strengthens interactions with host cell proteins and results in poor clearance of host cell proteins by protein A chromatography | Litcius