Aromatic Polyketides from the Mangrove-Derived <i>Streptomyces</i> sp. SCSIO 40069
Lili Sun, Hanning Zhu, Liping Zhang, Yiguang Zhu, Disna Ratnasekera, Changsheng Zhang, Qingbo Zhang
Abstract
A chemical investigation of Streptomyces sp. SCSIO 40069 resulted in the isolation of a series of aromatic polyketides with rare skeletons, including five new compounds RM18c–RM18g ( 1 – 5 ) and three known ones ( 6 – 8 ). Their structures and absolute configurations were determined by diverse methods, including HRMS and NMR spectra, chemical reaction, Snatzke’s method, quantum mechanical–nuclear magnetic resonance (QM-NMR), and X-ray crystallographic analysis. Compounds 1, 2, 4b, and 8 displayed moderate or weak antibacterial activities.
Topics & Concepts
MangroveStreptomycesStereochemistryQuantum chemicalStreptomycetaceaeChemistryMoleculeActinomycetalesOrganic chemistryBiologyBacteriaEcologyGeneticsMicrobial Natural Products and BiosynthesisMarine Sponges and Natural ProductsTraditional and Medicinal Uses of Annonaceae