Mild and Catalytic Synthesis of Pyrroles from Vinyl Ethynylethylene Carbonates
Jixing Li, Maoyan Liao, Haihui Zhu, Zhengyu Han, Jianwei Sun, Hai Huang
Abstract
A tandem remote propargylic amination/ring closure/aromatization reaction of vinyl ethynylethylene carbonates and amines has been developed, successfully constructing pyrrole derivatives. The reaction features mild conditions, high regioselectivity, high yields, and good functional group tolerance, making it an efficient method for pyrrole synthesis. Importantly, a variety of substrates containing natural product skeletons could also be compatibly and efficiently converted into pyrroles under the reaction conditions.
Topics & Concepts
AromatizationPyrroleRegioselectivityCatalysisChemistryAminationReaction conditionsFunctional groupRing (chemistry)Organic chemistryCombinatorial chemistryTandemCascade reactionMaterials sciencePolymerComposite materialSynthesis and Characterization of PyrrolesFluorine in Organic ChemistrySynthesis of Indole Derivatives