Membrane-cytoplasm translocation of annexin A4 is involved in the metastasis of colorectal carcinoma
Ya Peng, Zhaoyu Zhang, Ailing Zhang, Changhong Liu, Yingnan Sun, Zixuan Peng, Yang Liu
Abstract
concentration attenuated the small ubiquitin-like modifier (SUMO) modification of cytoplasmic ANXA4 and ANXA4 stabilization, and relatively high expression of ANXA4 promoted CRC tumorigenesis and epithelial-mesenchymal transition (EMT).
Topics & Concepts
Chromosomal translocationCytoplasmMetastasisAnnexinCancer researchAnnexin A2Colorectal cancerCarcinomaMedicineOncologyBiologyPathologyCell biologyInternal medicineCancerBiochemistryStainingGeneS100 Proteins and AnnexinsBiomarkers in Disease Mechanisms